منابع مشابه
Avoiding lentiviral transduction culture induced MSC senescence
colleagues in JCMM [1]. As noted by the authors, mesenchymal stem cells (MSC) enjoy considerable therapeutic potential in regenerative medicine, cell therapy for select genetic diseases and as immunomodulators [2, 3]. Expanding on a prior study that explored the genetic modification of MSC using HIV-1 derived lentiviral vectors, the authors describe a strategy that minimizes the replicative sen...
متن کاملCardiac Stem Cell Senescence in Ischemic Cardiomyopathy
We have recently demonstrated that human Cardiac Stem Cells isolated from explanted failing hearts (E-CSC) are characterized, in vitro, with respect to those isolated from healthy donors (D-CSC), by a senescent phenotype: a reduced telomere length and telomerase activity, telomere erosion, the occurrence of telomere dysfunction foci and the accumulation of senescent markers, as p16INK4A. In thi...
متن کاملPharmacologic Inhibition of Cardiac Stem Cell Senescence
Mammalian aging may be viewed as a reduction in the capacity to adequately maintain tissue homeostasis or to repair tissues after injury(Sharpless and DePinho, 2007). When homeostatic control diminishes to the point at which tissue/organ integrity and function are no longer sufficiently maintained, physiological decline develops, and aging becomes apparent. Cells that express senescence markers...
متن کاملCardiac Cell Senescence and Redox Signaling
Aging is characterized by a progressive loss of the ability of the organism to cope with stressors and to repair tissue damage. As a result, chronic diseases, including cardiovascular disease, increase their prevalence with aging, underlining the existence of common mechanisms that lead to frailty and age-related diseases. In this frame, the progressive decline of the homeostatic and reparative...
متن کاملCardiac Remodeling from Middle Age to Senescence
Background: The data on cardiac remodeling outside the scope of myocardial infarction and heart failure are limited. Methods: A cohort of middle-aged hypertensive subjects with age- and gender-matched control subjects without hypertension (n = 1,045, aged 51 ± 6 years) were randomly selected for the OPERA study (Oulu Project Elucidating Risk of Atherosclerosis study). The majority of those who ...
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ژورنال
عنوان ژورنال: Revista Argentina de Cardiología
سال: 2015
ISSN: 0034-7000,1850-3748
DOI: 10.7775/rac.es.v8.i4.4617